Does HFCS affect feelings of fullness?

No credible research has demonstrated that HFCS affects calorie control differently than sugar. A study by Pablo Monsivais, et al., at the University of Washington found that beverages sweetened with sugar and HFCS, as well as 1% milk, all have similar effects on feelings of fullness. (24)

Stijn Soenen and Margriet S. Westerterp-Plantenga, researchers at the Department of Human Biology at Maastricht University in The Netherlands, studied the effects of milk and beverages sweetened with sugar and HFCS on feelings of fullness. The researchers found “no differences in satiety, compensation or overconsumption” between the three beverages. (25)

Tina Akhavan and G. Harvey Anderson at the Department of Nutritional Sciences, Faculty of Medicine, University of Toronto studied the effect of solutions containing sugar, HFCS and various ratios of glucose to fructose on food intake, average appetite, blood glucose, plasma insulin, ghrelin and uric acid in men. The researchers found that sugar, HFCS, and 1:1 glucose/fructose solutions do not differ significantly in their short-term effects on subjective and physiologic measures of satiety, uric acid and food intake at a subsequent meal. (8)

Further, research by Almiron-Roig and co-workers in 2003 showed that a regular soft drink, orange juice and low-fat milk were not significantly different in their effects on hunger or satiety ratings, or in calories consumed at a subsequent meal. (26)